Welcome to the Daub Lab
We are a Karolinska Institute research group using clinical samples, high throughput sequencing and bioinformatics methods to understand the gene regulatory events underlying basic biological processes and to understand how these processes are dysregulated in diseases. We have extensive collaborations with clinical research groups from the Karolinska Hospitals allowing us to focus our work on human health based on human clinical samples.
The majority of the research group is placed in Stockholm, Sweden, at the Karolinska Flemingsberg Campus. Some group members are located at the Science for Life Laboratory (SciLifeLab) at the Karolinska Solna Campus.
Key words: Human disease; Clinical samples; Gene regulation; Gene expression; Bioinformatics; Transcription factor binding; Non-protein coding RNA; Gene enhancers; Functional validation
We demonstrated that differences in the acute transcriptional response to insulin are primarily driven by obesity per se, challenging the notion of human healthy obese adipose tissue, at least in severe obesity (Cell Rep. 2016 Aug 30;16(9):2317-26). Left: Transcriptional insulin response of human white adipose tissue; 29,964 CAGE tag clusters (15,398 genes) responding to euglycemic clamp. Right: Principal component analysis (PCA) showing the insulin response (transition from fasting (f) to hyperinsulinemia (h)) of non-obese (NO) as well as insulin sensitive (ISO) and insulin resistant (IRO) obese human individuals.